Transporters in Drug Discovery and Development: Detailed Concepts and Best Practice (Woodhead Publishing Series in Biomedicine)

Author: Lai PhD, Yurong

Brand: Woodhead Publishing

Edition: 1

ISBN: 9781907568213

Release Date: 26-12-2013

Package Dimensions: 9.4 x 5.1 x 1.6 inches

Languages: English

Binding: Hardcover

Number Of Pages: 780

Details: Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant polymorphism; drug transporter related pharmacokinetic, pharmacodynamics and toxicity; in vitro/in vivo probes of drug transport studies; the practical methodologies of industrial transporter screening and translational aspect in drug discovery and developments. A comprehensive overview of drug transporter families and their clinical relevance in drug discovery and development Balanced coverage of molecular biology aspects and functional outcomes State of art knowledge related to transporter-mediated DDI and the clinical relevance in pharmacokinetics, dynamics, and toxicity