GPCRs: Structure, Function, and Drug Discovery
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9780128162286, Academic Press, Beata, Jastrzebska PhD
Original price was: $202.30.$119.00Current price is: $119.00.
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Author: Jastrzebska PhD, Beata
Brand: Academic Press
Edition: 1
ISBN: 9780128162286
Release Date: 24-09-2019
Package Dimensions: 11.0 x 8.5 x 1.0 inches
Languages: English
Binding: paperback
Number Of Pages: 500
Details: GPCRS: Structure, Function, and Drug Discovery provides a comprehensive overview of recent discoveries and our current understanding of GPCR structure, signaling, physiology, pharmacology and methods of study. In addition to the fundamental aspects of GPCR function and dynamics, international experts discuss crystal structures, GPCR complexes with partner proteins, GPCR allosteric modulation, biased signaling through protein partners, deorphanization of GPCRs, and novel GPCR-targeting ligands that could lead to the development of new therapeutics against human diseases. GPCR association with, and possible therapeutic pathways for, retinal degenerative diseases, Alzheimer’s disease, Parkinson’s disease, cancer and diabetic nephropathy, among other illnesses, are examined in-depth. Addresses our current understanding and novel advances in the GPCR field, directing readers towards recent finding of key significance for translational medicine Combines a thorough discussion of structure and function of GPCRs with disease association and drug discovery Features chapter contributions from international experts in GPCR structure, signaling, physiology and pharmacology
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