Conceptual Background and Bioenergetic/Mitochondrial Aspects of Oncometabolism (Volume 542) (Methods in Enzymology, Volume 542)

Author: Galluzzi, Lorenzo

Brand: Academic Press

Edition: 1

ISBN: 9780124166189

Release Date: 10-06-2014

Package Dimensions: 9.1 x 6.1 x 1.2 inches

Languages: English

Binding: hardcover

Number Of Pages: 536

Details: Volume 542 of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This new volume covers research methods providing a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as “yet another” general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Provides theoretical overview on metabolic alterations of cancer cells, and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo