γδ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation (Breaking Tolerance to Anti-Cancer Cell-Mediated Immunotherapy)

Author: Barisa, Marta

Edition: 1

ISBN: 9780443217661

Release Date: 06-11-2024

Package Dimensions: 9.5 x 7.8 x 0.7 inches

Languages: English

Binding: hardcover

Number Of Pages: 208

Details: γδ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation sets out and critically discusses the current clinical and relevant preclinical γδ T cell immunotherapy landscape.
In five chapters, field experts discuss the challenges facing γδ T cell oncoimmunotherapy, propose solutions, and map next steps.

Particular attention is given to summarizing our understanding of the complex, translationally relevant human γδ T cell biology, the evidence basis for designing γδ T cell combination trials and data-driven perspectives on what is known―and what isn’t―about γδ T cell therapeutic persistence. Various perspectives are provided on how issues of cytotoxic effector function, functional exhaustion, and cytokine addiction can be mitigated using gene engineering.
A chapter is dedicated to the systematic review of all γδ T cell immunotherapy trials to date, and the cell therapy products that were used in these trials. The final chapter discusses allograft persistence-enhancement techniques in the context of γδ T cell therapy, covering lymphodepleting chemotherapy and synthetic stealth engineering.

γδ T Cell Cancer Immunotherapy: Evidence-Based Perspectives for Clinical Translation gives an updated and comprehensive insight into the current state of γδT cell immunotherapy, which is of interest to existing translational γδ T cell specialists, the proliferating range of academic scientists and commercial scientists entering the field, as well as clinicians who may encounter γδ T cell immunotherapy in the clinic, or are wishing to familiarize themselves with noncanonical lymphocyte immunotherapy. Summarizes the cutting edge of oncology-relevant γδ T cell immunobiology Lays out clinical successes and failures to date Addresses the possible advantage of combining γδ T cell-based immunotherapy with conventional chemotherapy or checkpoint blockers Provides an up-to-date and well-rounded discussion of a translationally, commercially, and scientifically relevant field