The Aptamers Ligands: Powerful Tools from Molecular Evolution
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9781785482137, Elsevier, Gerald, Perret
Original price was: $144.50.$85.00Current price is: $85.00.
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Author: Perret, Gerald
Brand: Elsevier
Edition: 1
ISBN: 9781785482137
Release Date: 15-12-2019
Languages: English
Binding: hardcover
Number Of Pages: 200
Details:
The Aptamers Ligands: Powerful Tools from Molecular Evolution discusses these short, single strand oligonucleotides that can fold in a three-dimensional conformation and how they can provide a precise molecular recognition of a given target. These nucleic acid based ligands are identified from large naive combinatorial oligonucleotide libraries using a well-established technology called SELEX (systematic evolution of ligands by exponential enrichment). Aptamers can be extremely specific towards their target molecule with high selectivity and proper affinity dissociation constants. Moreover, they can be selected to recognize a high diversity of molecules, from very small compounds, to large macromolecules, such as proteins.
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