Long Non-coding RNA: The Dark Side of the Genome

Author: Morillon, Antonin

Brand: Elsevier

Edition: 1

ISBN: 9781785482656

Release Date: 31-01-2018

Package Dimensions: 9.1 x 6.0 x 0.7 inches

Languages: English

Binding: hardcover

Number Of Pages: 190

Details: The dark side of the genome represents vast domains of the genome that are not encoding for proteins – the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function.
This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology.
Using classical examples and an extensive bibliography, the book illustrates the most studied and attractive examples of these long non-coding RNA, how they interface with epigenetics, genome integrity and expression and what are the current models of their regulatory mechanisms.
This book offers a large review about the long non-coding RNA It presents the broad functional diversities of those molecules It presents pioneer works from the field Provides a comprehensive review of the field Presents fundamental and therapeutic interests